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Please click on the below links to access articles on malaria, the use of artemisinin-based combination therapies (ACTs), and details of this project.
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Links to Articles:
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Ro, Dae-Kyun et al. "Production of the Antimalarial Drug Precursor Artemisinic Acid in Engineered Yeast." Nature. 2006. This paper describes the engineering of a strain of yeast to produce artemisinic acid, a precursor to the anti-malarial agent artemisinin produced by the plant Artemisia annua. Through engineering its mevalonate pathway, the yeast was able to produce high amounts of isoprenoid precursor. The artemisinic acid biosynthetic genes were expressed in the engineered yeast strain, including a cytochrome P450 gene which was identified de novo. This unusual cytochrome P450 catalyzes three successive oxidations of the substrate. Up to 100 mg of artemisinic acid per 1 culture were produced by this strain.
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"Animated Lifecycle of Plasmodium." This brief video illustrates the life cycle of Plasmodium, the malaria parasite. It covers the complete cycle, including human and mosquito hosts.
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